By combining the levels of serum IL-6, IL-9, and IL-17 with the clinical risk factors creatinine and LDL-C, the risk prediction model constructed in this study may contribute to the evaluation of CAD severity and may provide a clinically useful, low cost, and low risk tool to facilitate the decision-making process for performing angiography in symptomatic patients, especially in primary health facilities and in the catheter lab resource-limited settings. Here, IL9 is linked to coronary artery disorder.