Compared with patients with low GS, those with high GS had higher levels of serum TNF-α (P < 0.01), IL-6 (P < 0.01), IL-9 (P < 0.01), IL-10 (P < 0.01), and IL-17 (P < 0.01), exhibiting a close relationship between these cytokines and the severity of CAD (Figure 1). The gene discussed is TNF; the disease is coronary artery disorder.