ITGA2B and acute coronary syndrome: The role played by GP IIb/IIIa inhibitors has continuously evolved from the initial introduction in mid 90s until the most recent guidelines for treating acute coronary syndromes, and competed with a wider use of ADP inhibitors and novel anticoagulant drugs, to the extent that they stepped down from class I to class II recommendation in the routine setting of acute coronary syndromes [8, 9].