In the PLATelet inhibition and patient Outcomes (PLATO) trial, long-term reversible P2Y12 inhibition with ticagrelor was better than that with clopidogrel for the prevention of cardiovascular and total death, stent thrombosis, and myocardial infarction without an increase in the rates of major bleeding in a broad population of patients with acute coronary syndromes who were started on treatment as soon as possible after hospital admission [24]. The gene discussed is P2RY12; the disease is myocardial infarction.