The Aliskiren and Valsartan to Reduce NT ProBNP via Renin-Angiotensin-Aldosterone-System Blockade (AVANT GARDE)-TIMI 43 study enrolled 1,101 patients with elevated NT ProBNP (> 400 pg/mL) 3 - 10 days after an acute coronary syndrome (ACS) event [16]. Here, NPPB is linked to acute coronary syndrome.