Since NSCLC are often associated with the presence of intratumoral tertiary lymphoid structures (15), it is conceivable that these ectopic lymphoid tissues, as well as the establishment of a lymphoid-like stroma within the tumor, might drive the expression of chemokines normally secreted in secondary lymphoid organs (CCL19, CCL21, etc.)and, therefore, preferentially attract CD56bright non-cytotoxic NK cells at the tumor site (Figure 1). The gene discussed is CCL21; the disease is neoplasm.