In addition, IL-17+-producing CD4+ T cells (TH17) were significantly higher in patients with IgG4-RD compared to HC (1.0 ± 0.17% versus 0.7 ± 0.17%; p = 0.02) but not to patients with pSS. This evidence concerns the gene CD4 and immunoglobulin G4-related sclerosing disease.