On the other hand, Yu et al.’s (2015a) group demonstrated that TMZ inhibits the cell proliferation and promotes apoptosis through inhibiting the PI3K/AKT/mTOR signaling pathway, and the dual PI3K-mTOR inhibitor NVP-BEZ235 enhances the cytotoxicity of TMZ for GBM. This evidence concerns the gene AKT1 and glioblastoma.