Recent studies reported that DR6 expression is upregulated in neurodegenerative disease such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) and the upregulated expression of DR6 may contribute to the pathogenesis of these neurodegenerative disorders [37, 38]. The gene discussed is TNFRSF21; the disease is amyotrophic lateral sclerosis.