The impact of polymorphic variants of glutathione S-transferases (GSTs), cytochrome P450s (CYPs), methylenetetrahydrofolate reductase (MTHFR), and methionine synthase reductase (MTRR) on BC risk might be reflected by an association with the frequency of somatic mutations in the TP53 gene [6]. This evidence concerns the gene HPGDS and breast cancer.