SLC7A11 and neoplasm: Given that SLC7A11 expression predicts and regulates tumour sensitivity to the prototypical mut-p53 reactivator, APR-246, we next examined the relationship between mut-p53 and SLC7A11. We found that SLC7A11 mRNA and protein levels inversely correlated with accumulation of mut-p53 protein across our oesophageal cell line panel (Fig. 4a,b).