Consistent with this, analysis of multiple microarray datasets from the NCI-60 cell line panel (a panel of 60 diverse human cancer cell lines used by the National Cancer Institute for therapeutic development12, 13) demonstrated that SLC7A11 expression correlated more strongly with response to the APR-246 lead compound PRIMA-1 than any other gene (Supplementary Fig. 3a,c). Here, SLC7A11 is linked to cancer.