MTOR and neoplasm: mTOR inhibition repressed tumour growth in WHIM18 and WHIM20 (ANOVA followed by Tukey's post hoc test, P=9.5e-10, 1.6e-03 respectively), but not in WHIM16 (P=0.97), showing that inhibition of mTORC1/2 may effectively suppress breast tumours with activated AKTs and validating a previous study showing the efficacy of mTOR inhibition in PDX models of triple-negative breast cancer34.