Interestingly, we also identified overexpressed proteomic events not evident in the genomic level in both PDX and human samples, including outlier protein expression of EGFR, and outlier phosphosite expressions of ARAF, BRAF, HSP90AB1, PTPN11 and TOP2A (Fig. 6), highlighting potential new treatment opportunities in breast cancer. The gene discussed is TOP2A; the disease is breast cancer.