VEGFA and glioblastoma: Intriguingly, cell-by-cell patterning of VE-cadherin at individual EC–EC junctions was also shown to switch from a differential pattern to large contiguous groups of cells with either all high or all low junctional activity in a number of different high VEGF tissues: glioblastoma vessels, mouse retinas intraocularly injected with high levels of VEGF-A or exposed to OIR [51].