HPN and preeclampsia: We found these peptides upregulated in pregnant SHRSP rats, as well as in urine samples from 2 independent cohorts of women with preeclampsia in other work.22,23 This sequence 592 to 609 consisted of the polymerization-inhibitory motif (601–610), downstream of the hepsin cleavage site (R591) and upstream of glycosylphosphatidylinositol anchoring.