It was reported that IL-8 is increased in the vitreous fluid in retinal artery occlusion and proliferative diabetic retinopathy [8], and aqueous concentration of IL-8 have been shown to increase with progression of diabetic retinopathy from mild to severe non-proliferative diabetic retinopathy [27]. The gene discussed is CXCL8; the disease is proliferative diabetic retinopathy.