Second, high plasma potassium is associated with reduced activity of the renin-angiotensin-aldosterone system, which has been shown to slow progression of renal disease [42], whereas hypokalemia was reported to stimulate renin and angiotensin II despite direct suppression of aldosterone synthesis leading to salt-sensitive hypertension, intrarenal vasoconstriction and ischemia [10,43–45]. The gene discussed is REN; the disease is ischemia.