SC obtained 7 days after infection with S. mansoni from mice that were immunized with SmCL3 alone, SmCL3 + SmCB1 or SmCL3+ SmCB1 + SG3PDH did not release IL-5, IL-13, IL-17 or IFN-γ when stimulated with SmCL3, yet released IL-4 in response to SmCL3 and especially SmCB1, similarly to the observation reported previously with SmCB1 and FhCL1 [14]. This evidence concerns the gene IL5 and infection.