A vaccine that combined SmCB1 and SmCL3 with another secreted molecule, S. mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH), induces predominant type 2 immune responses, and consistently evokes superior protection (>70%) against S. mansoni challenge infection in both outbred CD-1 mice and hamsters. This evidence concerns the gene GAPDH and infection.