A vaccine combining SmCB1 and SmCL3 with another secreted molecule, S. mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH), which is also located at the host-parasite interface [17–19], elicited impressive levels (>70%) of protection to S. mansoni challenge infection suggesting that this efficacious trivalent vaccine should now be brought forward into trials in non-human primates for assessment as a potential vaccine to control human schistosomiasis. This evidence concerns the gene GAPDH and infection.