WNT1 and Global developmental delay: The palate of both Ttc21bf/aln;Wnt1-Cre and Ttc21bf/aln;Crect were cleft, however Ttc21bf/aln;Wnt1-Cre palatal shelves appeared to be elevated and patent due to either developmental delay or palatal insufficiency, whereas the palatal shelves in the Ttc21bf/aln;Crect were hypoplastic and dysmorphic (Fig 7E–7G).