SETBP1 and cancer: The group of individuals who developed cancer carry SETBP1 mutations which are more disruptive to the interaction of SETBP1 with βTrCP1 than the group of patients who did not develop cancer (Fig 5; βTrCP1 interaction ΔΔG = 3.57 vs 0.65, p = 0.029, Mann-Whitney U test).