Moreover, inflammation (hepatic HAI, serum ALT, AST, TNF-α, IL-1β, IL-6, IL-18, apoptosis degree) and oxidative stress related (serum MDA, mitochondrial H2O2) biomarkers were significantly increased while body weight, TG and mitochondrial ATP level was significantly decreased in NASH group than those in controls (Fig 1C, Table 1). The gene discussed is IL18; the disease is metabolic dysfunction-associated steatohepatitis.