Our observation that a positive association between the eNOS Glu298Asp variant and LAA stroke is consistent with the findings that the eNOS Glu298Asp polymorphism is in association with coronary artery disease and myocardial infarction among different ethnic cohorts, including Korean, Italian, North Indian, Turkish, and Han-Chinese population [31–35]. The gene discussed is NOS3; the disease is coronary artery disorder.