An individual vulnerability of eNOS and Cav-1 polymorphisms to the pathogenesis among cardiovascular diseases has been studied [13–17], yet the correlation between genotypic polymorphisms of these two genes and the synergistic interaction of eNOS/Cav-1 on susceptible risk of large artery atherosclerotic (LAA) stroke has never been reported. The gene discussed is CAV1; the disease is cardiovascular disorder.