CAV1 and familial hypercholesterolemia: Besides, carriers with the Cav-1 G14713A polymorphism showed an elevated IS risk among those subjects within the same categorization of the clinical parameters, including hypercholesterolemia (aOR = 2.46, 95% CI = 1.42–4.27) and heavy cigarette smoking (aOR = 3.46, 95% CI = 1.75–6.84), Similarly, observations of the effects of hypercholesterolemia and heavy cigarette smoking on LAA stroke risk elevation were statistically significant in patients with the Cav-1T29107A variant genotype (TA/AA) (P < 0.05) (Table 3).