NOS3 and familial hypercholesterolemia: As summarized in Table 3, a greater proportion of the eNOS 894GT and TT variants was seen in cases, showing a 3.23-fold risk increase in patients with hypercholesterolemia (95% CI = 1.70–6.12) and a 3.50-fold risk in patients with a long-term habit of heavy cigarette smoking (95% CI = 1.75–6.99).