MUC5B and type 2 diabetes mellitus: In the joint common and rare variant analysis (12,244 genes), we observed a significant association between T2D and variants in the MUC5B gene (mucin 5B, oligomeric mucus/gel-forming, GeneID: 727897, 11p15.5) with p-value of 1.01 × 10−14 (Table 2; Fig 1 and QQ plot S1 Fig).