In breast cancer cells, the ability of Lpd to promote 3D invasion relies on its interactions with both Ena/VASP and Scar/WAVE.15 Although both ena and scar were capable of cooperating with RasV12 in our model, their effect was modest compared to the effect of chic (Drosophila Profilin). The gene discussed is RPS4X; the disease is breast carcinoma.