EGFRwt activates the NF-κB in glioma cells via an SHP-2 (SH2-containing tyrosine-specific protein phosphatase) and Gab1 (Growth factor receptor-bound protein 2/GRB2 associated binding protein1)-dependent pathway, and via a PLCγ and PKCε-dependent pathway. This evidence concerns the gene NFKB1 and glioma.