One putative tumor suppressor is the homolog of SAMD9, SAMD9L. SAMD9L and SAMD9, together with the HEPACAM2 gene, are located on 7q21.1 (Figure 1B), a region that has been found to be deleted in a subset of patients with myeloid leukemia and myelodysplastic syndromes (9). The gene discussed is SAMD9L; the disease is myeloid leukemia.