SAMD9 and myelodysplastic syndrome: Similarly, loss of SAMD9 and SAMD9L by monosomy 7 or monosomy 7q (–7/7q–) is well established in myeloid lineage malignancies (8, 9), and disruption of SAMD9L has been shown to be associated with the development of myelodysplastic syndrome (MDS) in mice and humans (10, 11).