Interestingly, a strain homozygous for IDP2-R132H had less stable gene silencing than the heterozygous strain, suggesting that the effect of IDP2-R132H on silencing was synergistic with a wild-type copy of IDP2. These results echoed the observation in IDH1R132H/WT tumor cell lines that knockout of the wild-type copy of IDH1 (IDH1R132H/-)  results in decreased D2-HG formation relative to IDH1R132H/WT cells (Jin et al., 2013). This evidence concerns the gene IDH1 and neoplasm.