Altogether, these data not only support the reliability of our IPA analysis but suggest a putative complex cooperation among methylation at the three MIR9 promoters, chromatin remodelling factors and transcriptional regulators including the NF-kB complex and FOXA1, which fine tune miR-9-5p expression levels in both tumour and normal epithelial components. Here, NFKB1 is linked to neoplasm.