APOE and atherosclerosis: While such discrepancy could be attributed to differences in species (rat vs. mice), Cr3+ formulation and dose as well as animal models (wild-type vs. ApoE−/−) utilized, it is important to note that the reduced susceptibility to atherosclerosis in CrP-treated mice was not related to lower lipid profiles in these animals; indeed, plasma total cholesterol and total triglyceride levels were not significantly different between hyperglycemic ApoE−/− mice treated with and without CrP.