A slight increase in the percentage of PD-L1 expression on MDSC and TAM was also observed (Supplementary Fig. 2b,d); and the absolute number of PD-L1+ MDSC and PD-L1+ TAM was significantly increased as the overall numbers of MDSC and TAM were elevated post virus infection (Fig. 2c,d, Supplementary Fig. 2c,e). The gene discussed is CD274; the disease is viral infectious disease.