Moreover, although higher levels of LOX-1 was detected in advanced-stage (TNM III/IV) than in early-stage (TNM I/II) tumors, the early- or advanced-stage GC patients with low LOX-1 expression all have longer OS than those with high LOX-1 expression, indicating that controlling LOX-1 expression may be a promising target for GC treatment regardless of TNM stage. The gene discussed is OLR1; the disease is gastric cancer.