As shown in Fig. 3a, LOX-1 expression (HR, 3.744; 95% CI, 1.748–8.017; P = 0.001), tumor size (HR, 1.897; 95% CI, 1.116–3.226; P = 0.018), along with distant metastasis (HR, 2.440; 95% CI, 1.110–5.362; P = 0.026) were identified as independent prognostic factors for OS in patients with GC. This evidence concerns the gene OLR1 and gastric cancer.