WT1 expression in other adult tumours is usually associated with higher histological grade as well as worse prognosis59, 60 and several hypotheses have been formulated to explain this association, such as altered proliferation/apoptosis16, 17, 18, 19, increased angiogenesis25, 26, 27 and induction of cancer-EMT1. The gene discussed is WT1; the disease is cancer.