Interestingly, mitochondrial malfunction seems to be associated with lysosomal impairments, both in acute (TFAM−/− T cells upon activation)14 and chronic stress (e.g., OPA1−/−, AIF−/− MEFs)26, characterized by enlarged dysfunctional lysosomes akin to the saturated organelles observed in lysosomal storage diseases. This evidence concerns the gene OPA1 and lysosomal storage disease.