Interestingly, mitochondrial malfunction seems to be associated with lysosomal impairments, both in acute (TFAM−/− T cells upon activation)14 and chronic stress (e.g., OPA1−/−, AIF−/− MEFs)26, characterized by enlarged dysfunctional lysosomes akin to the saturated organelles observed in lysosomal storage diseases. Here, AIFM1 is linked to lysosomal storage disease.