To confirm the relationship between RELN expression profile and matched clinical information in a larger cohort of patients with multiple myeloma, a publicly available Gene Expression Omnibus (GEO) database, including 565 newly diagnosed MM patients (USA) from GSE24080 (Affymetrix HG-U133_Plus_2.0 array) (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24080) was analyzed15. This evidence concerns the gene RELN and Miyoshi myopathy.