VEGFA and cancer: For example, the inhibition by oxamic acid of LDH production by cancer cell lines potentiates the antiproliferative activity of tyrosine kinase inhibitors such as sorafenib28, Moreover, patients with high pretreatment levels of LDH may represent optimal candidates for inclusion in clinical trials that employ a multimodality treatment approach (e.g. transcatheter arterial chemoembolization and inhibitors of vascular endothelial growth factor signaling) to improve time to progression and OS29.