The evaluation of Lgr5+ HF stem cells in TM-treated Lgr5-Cre:Ptenflox/flox mice after wounding revealed increased numbers of Lgr5+ (GFP+) cells in the upper portion of the HF at PWD-3 and in the re-epithelized epidermis at PWD-5 compared with the numbers seen in untreated mice (Fig. 6d,e). The gene discussed is LGR5; the disease is hydrops fetalis.