Importantly, TM-induced Pten loss in Lgr5+ HF stem cells in Lgr5-Cre:Ptenflox/flox mice (1-cm diameter wound at P35–42) promoted a number of neogenic HFs in the wound, while neogenic HFs were rarely observed in control mice (Fig. 6f,g). The gene discussed is LGR5; the disease is hydrops fetalis.