LGR5 and hydrops fetalis: Moreover, the intracutaneous injection (local treatment) of TM induced HF TAT (second telogen, 8–9-week-old mice) at the injection site (Fig. 5b), and the intraperitoneal administration (systemic treatment) of TM induced widespread HF TAT in the back skin of these mice (Fig. 5c), indicating that Pten knockout in Lgr5+ cells at second telogen could make the second telogen shorter.