Interestingly, anagen HFs were barely induced in wounded TNFR1−/− mice, while the wounding of TNFR2−/− mice induced similar levels of anagen HFs as wild-type mice (Fig. 3e,f), indicating TNF activates HFs largely through TNFR1. The gene discussed is TNFRSF1B; the disease is Hand-foot syndrome.