Impressively, the knockout of β-catenin expression with Pten in Lgr5-Cre:Ptenflox/flox:β-cateninflox/flox mice (P35–42) completely blocked Pten loss-induced HF neogenesis in the wound, suggesting that β-catenin is the crucial mediator in AKT-promoted HF neogenesis (Fig. 6f,g). Here, AKT1 is linked to hydrops fetalis.