AIM2 and infection: Activation of the DNA sensor AIM2 by infection with the Gram-negative bacterium Francisella novicida, transfection of dsDNA ligand poly(dA:dT) into the cytoplasm or infection by the DNA virus mouse cytomegalovirus (MCMV) leads to assembly of the inflammasome27, 28, 29, 30, 31, 32, 33, 34.