In contrast, only 35% of the Casp11−/− mice (6/17, P < 0.0001 compared with WT) and 14% Casp1−/−Casp11−/− (1/7, P = 0.0014 compared with WT) mice succumbed to endotoxemia (Fig. 3C). Here, SCAF11 is linked to serum lipopolysaccharide activity.