CASP1 and infection: A further study has found that the caspase-11-expressing mouse strain Casp1−/−Casp11Tg (generated via microinjection of a bacterial artificial chromosome transgene encoding caspase-11 into Casp1−/−Casp11−/− mouse embryos) revealed that they were more susceptible to infection with S. Typhimurium than Casp1−/−Casp11−/− mice65.