Notably, MYXV selectively deletes MM cells from PBMCs or BM from patients ex vivo without harming CD34+ HSCs because normal stem cells are incapable of binding MYXV.15, 16, 17, 18, 19 The fate of MYXV-infected human MM cells is a rapidly induced apoptosis that is triggered through activation of the extrinsic caspase-8 pathway.20 This evidence concerns the gene CASP8 and Miyoshi myopathy.