TP53 and lung carcinoma: Similarly, when using a p53-null human lung carcinoma cell line with inducible p53 (H1299-p53-tet-on), induction of p53 using doxycycline (Figure S3) did not affect cytotoxicity of EnAd, Ad11p, or Ad5, although it did increase cisplatin cytotoxicity as expected (Figure 3C).