SOD1 and amyotrophic lateral sclerosis: When we differentiated human ALS iPSCs into MNs using SeV-L-N-I (Figures S5C and S5D), SOD1-ALS iPSC-derived neurons presented an accumulation of misfolded SOD1 (Figures 6A and 6B), and TDP-43-ALS iPSC-derived neurons exhibited cytosolic TDP-43 aggregation (Figures 6C and 6D).