Next, we generated iPSCs from embryonic fibroblasts of ALS model mice carrying mutant SOD137 or mutant TDP-4338 or from littermate controls by transducing Oct3/4, Sox2, Klf4, and c-Myc, as previously reported39, 40 (Figure S6A; Table S5). Here, MYC is linked to amyotrophic lateral sclerosis.