Fatty acid oxidation has been shown to attenuate inflammatory and endoplasmic reticulum stress responses in human macrophages.54, 55 Thus, the anti-inflammatory potency and NASH-protective effect of the anti-CD163-dexamethasone conjugate in rats on HFr diet might to some extent relate to increased β-oxidation of fatty acids originating from the conversion of fructose to triglycerides. This evidence concerns the gene CD163 and metabolic dysfunction-associated steatohepatitis.