We show that HCC patients with low tumor PD-L1 expression and CD8+TIL infiltration (type II tumors), which suggests tumors with immune ignorance, according to the model by Teng et al.,35 have the worst prognosis (Fig. 5A), whereas patients with high tumoral PD-L1 expression and TIL infiltration (type I tumors), which suggest adaptive immune resistance, have the best prognosis, as predicted. The gene discussed is CD274; the disease is hepatocellular carcinoma.