Concordant with our findings in the tumor center, the infiltrative margin of MSI tumors contained more CD45RO+ lymphocytes (MSI vs NSMP p = 0.002, MSI vs p53 p = 0.003) and more TIA-1+ cytolytic T-lymphocytes (MSI vs NSMP p = 0.002, Fig. 2C). Here, TP53 is linked to neoplasm.