Staining for cytotoxic T-lymphocyte marker CD8+ and the intraepithelial T-lymphocyte marker CD103+ revealed similarly increased infiltrate in the tumor center (comparison of CD8+ cells: POLE vs NSMP p < 0.001; POLE vs p53 p = 0.021; MSI vs NSMP p = 0.016, comparison of CD103+ cells: POLE vs MSI p = 0.023; MSI vs NSMP p = 0.035; MSI vs p53 p = 0.030). Here, TP53 is linked to neoplasm.