ERBB2 and breast carcinoma: Another trial that evaluated a nab-paclitaxel–containing backbone regimen was the phase II TBCRC 008 study, which compared 12 weeks of neoadjuvant carboplatin, nab-paclitaxel 100 mg/m2 qw, and vorinostat vs carboplatin, nab-paclitaxel 100 mg/m2 qw, and placebo for operable, stage II–III, HER2-negative breast cancer [15].