Patients who received nab-paclitaxel plus gemcitabine vs nab-paclitaxel plus carboplatin experienced a significantly higher frequency of dose reductions (20.6 vs 11.9%; P = 0.03), treatment-related severe adverse events (13 vs 5%; P = 0.02), grade 3–4 infections (6.1 vs 1.3%; P = 0.04), and alanine aminotransferase elevations (11.7 vs 3.3%; P = 0.01). The gene discussed is GPT; the disease is infection.