The ETNA trial, another ongoing phase III study (NCT01822314; planned N = 632), is evaluating single-agent nab-paclitaxel 125 mg/m2 qw 3/4 vs paclitaxel 90 mg/m2 qw 3/4 as neoadjuvant therapy for high-risk HER2-negative breast cancer [https://clinicaltrials.gov/ct2/show/NCT01822314]. This evidence concerns the gene ERBB2 and breast cancer.