CAMK4 and systemic lupus erythematosus: Interestingly, both SLE patients and lupus-prone mice possess decreased numbers and abnormal function of Tregs69–72 while exhibiting increased calcium/calmodulin-dependent protein kinase IV (CamK4)73,74, which is responsible for an imbalance in Th17 cells and Tregs with a shift towards more Th17 cells.