CTLA4 and neoplasm: In contrast, when Dewan et al. used radiation regimens of 20 Gy × 1, 8 Gy × 3, and 6 Gy × 5 in combination with anti-CTLA-4 antibody, they found that the fractionated doses were more effective in inhibiting tumor growth outside of the field of radiation compared to the single-dose regimen [35].