A large body of preclinical data has been published on the use of RT with immunostimulatory molecules such as interleukin-2 (IL-2), FMS-like tyrosine kinase 3 ligand (Flt3-L), and Toll-like receptor (TLR) ligands to generate the abscopal effect in mouse models of renal cell carcinoma, breast cancer, and colon cancer. This evidence concerns the gene IL2 and malignant colon neoplasm.