eIF4E also interacts with the 5′-terminal cap of mRNA and was initially named the ‘cap-binding protein.’ Moreover, eIF4E and its isoform eIF(iso)4E are functionally redundant and one or both of them interact with HCpro and VPg, which are indispensable for viruses to complete their infection cycle; therefore, abolishing this interaction may prevent the viral infection (Lellis et al., 2002; Browning, 2004; Kang et al., 2005; Jin et al., 2007; Charron et al., 2008; Ala-Poikela et al., 2011; Wang and Krishnaswamy, 2012; Sanfacon, 2015). Here, EIF4E is linked to viral infectious disease.