PTGS2 and hypertensive disorder: Though the mechanism is unclear, animal studies suggest that COX-2-inhibition plays a role in attenuating the effects of Angiotensin II (AngII; Wu et al., 2005; Martínez-Revelles et al., 2013) the effector molecule of the renin angiotensin system (RAS), which plays a central role in the pathophysiology of hypertension, an important risk factor for cardiovascular disease (Touyz and Schiffrin, 2004; Mehta and Griendling, 2007).