In the present study, we found that MEV cascade inhibition by the HMGCR inhibitor simvastatin induced intrinsic apoptosis cell death and decreased mitochondrial membrane potential in a broad range of human tumor cell lines, including glioma (U87, U251), neuroblastoma (SH-SY5Y), lung (A549, H460, H1650, H1975), and breast cancer cells (MCF7, MDA-MB231). Here, HMGCR is linked to breast carcinoma.