BECN1 and cystic fibrosis: Moreover, it has been observed that the defective CFTR protein leads to an autophagy inhibition by Beclin1 sequestration in aggresomes in airway epithelial cells, and that the restoration of autophagy by overexpression of Beclin1 restored CFTR trafficking, reduced its accumulation in aggresomes and reverts the CF airway phenotype [138].