Treatment of APL patients with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) leads, over a period of 1 to 3 weeks, to normalization of plasma concentrations of D-dimers and thrombin–antithrombin complexes [7, 8, 16, 17] and of TF mRNA in patient-derived bone marrow cells [8, 16, 18]. Here, TF is linked to acute promyelocytic leukemia.