Pathogenesis of the coagulopathy is complex and includes an insufficient production of platelets, as well as disseminated intravascular coagulation (DIC) [2, 6–9], caused, at least in part, by tissue factor (TF) expressed on the leukemia cells and on leukemia cell-derived microparticles expressing TF and procoagulant phosphatidylserine on their surface [10–14]. This evidence concerns the gene TF and Disseminated intravascular coagulation.