The consequences of potential effects of NF-κB inhibition on APL cell survival should be carefully evaluated, as the apoptotic cells and the cell-derived microparticles express phosphatidylserine at their surface and may thereby exacerbate thrombo-hemorrhagic complications, despite an initial reduction in TF mRNA, but not yet in TF protein. This evidence concerns the gene TF and acute promyelocytic leukemia.