SNCA and multiple system atrophy: Future deep phenotyping approaches in longitudinal cohorts may help to further differentiate between advPD and AP and define mechanism-based therapeutic approaches that can be applied to different clinical entities, e.g., PD and MSA as synucleinopathies as currently investigated for green tea component Epigallocatechin-gallate (EGCG) that interferes with alpha-synuclein aggregation in vitro and in vivo (Levin et al. 2016).